The Analytical Study of Antigenicity and Mhc Binder of the Cytochrome C Oxidase Subunit I

نویسندگان

  • Sonu Mishra
  • Virendra S. Gomase
  • Karbhari V. Kale
چکیده

In this study we will summarize the potency of Cytochrome c oxidase subunit I (mitochondrion )from Dracunculus medinensis with526 amino acids. Antigenic peptide of cytochrome c oxidase subunit I (mitochondrion) protein is most suitable for subunit vaccine development because with single epitope, the immune response can be generated in large population. In this investigation, we used PSSM and SVM algorithms for the prediction of MHC class I & II binding peptide, antigenicity, solvent accessibility, polar and nonpolar residue to analyse the regions that are likely exposed on the surface of proteins which are potentially antigenic that allows potential targets to identify the active sites against infection as well as to design effective drug to treat it.

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تاریخ انتشار 2016